That IS a good one.
I think my big one is I don’t personally go with Pluto/Setsuna being a Ravenclaw, which I see a lot. She’s smart, definitely, and has such a vast store of knowledge, but I don’t know that she’d really value knowledge for knowledge’s sake the way ‘claws do. I think for me it comes down between Hufflepuff and Gryffindor, because her loyalty and duty and love are the most central things to her, and Gryffindor edges ahead.
The few Ravenclaws in HP canon came off as pretty cerebrally-orientated, and I see Setsuna as being led a lot more by her heart. She could watch the Silver Millenium burn not because there’s calculated thought behind doing so or anything, but because guarding the time gate is the one thing she can do, her last act of love for her queen and the rest of her people. And then, in every canon, which she gets a chance to do more, she loves enough and is brave enough to lay down her life.
So to me, Setsuna’s pretty firmly a Gryffindor.